Microbial biochemistry incorporates of biochemical reactions in microbial growth, different mechanisms/ techniques of pathogenesis required in inflicting contamination/ illnesses in the host. It consists of studies related to of growth, cell shape, metabolism, functions and the interactions of biological macromolecules, like carbohydrates, proteins, Fatty Acids and Lipids and nucleic acids of microbes; which cater the skeletal component and foundation of capabilities affiliated with lifestyles. Biochemical research of microbes is important in the mode of their action. Post genomic analyses, mechanisms, & replication, integrating plasmid functions, conjugation structures and regulatory network are the key factors that play a critical function in metabolism of microbes. While monomers are co-connected to synthesize a polymer, dehydration takes place regularly ensuing in assembly of various macromolecules in tons large complexes.